The Role of Doublecortin-like in the Suprachiasmatic Nucleus

  • Boris Polm ScienceWorks, Student Research Conference 2016

Abstract

The hypothalamic Suprachiasmatic Nucleus (SCN) is known as the central biological clock that regulates circadian rhythmicity in mammals. Through vasopressin (AVP) processing in its shell, the SCN signals to other brain areas and peripheral organs in the body. A novel protein, Doublecortin-like (DCL) was identified to have overlapping expression with that of AVP. Mice with SCN-specific DCL-knockdown show abnormal activity adaption after a change in light-phase, and immunohistochemical AVP staining indicate a distortion of AVP in the SCN of DCL-knockdown mice. Together, we conclude that DCL may be a novel regulator of AVP signalling in the SCN.
How to Cite
POLM, Boris. The Role of Doublecortin-like in the Suprachiasmatic Nucleus. Student Undergraduate Research E-journal!, [S.l.], v. 2, dec. 2016. ISSN 2468-0443. Available at: <https://journals.open.tudelft.nl/index.php/sure/article/view/1495>. Date accessed: 26 may 2019.
Published
2016-12-08