Detection of novel Lipid II-targeting antibiotics from fungi

Authors

  • Irene Zaalberg Utrecht University

DOI:

https://doi.org/10.25609/sure.v5.4193

Keywords:

Antibiotics, Lipid II, fungi, resistance

Abstract

Bacterial resistance to antibiotics is one of the biggest
threats to global health today. Therefore, there is a pressing
need for new antibiotics. In this study, we examined four
fungal strains for novel Lipid II-targeting antibiotic
compounds. To do this, we analyzed fungus-extracted
fractions by antibacterial activity assays in which Lipid II
was included to detect antagonism, TLC and LC-MS. We
identified eighteen Lipid II-targeting active fractions.
Further purification and characterization of one active
compound suggested a hydrophobic nature and a
corresponding m/z value of 805 or 1300. Further research
should elucidate the structure of the compound.

Additional Files

Published

2019-12-03

How to Cite

Zaalberg, I. (2019). Detection of novel Lipid II-targeting antibiotics from fungi. Student Undergraduate Research E-Journal!, 5, 1–4. https://doi.org/10.25609/sure.v5.4193

Issue

Vol. 5 (2019): Student Research Conference 2019

Section

Medical Research

License

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