Detection of novel Lipid II-targeting antibiotics from fungi

  • Irene Zaalberg Utrecht University

Abstract

Bacterial resistance to antibiotics is one of the biggest
threats to global health today. Therefore, there is a pressing
need for new antibiotics. In this study, we examined four
fungal strains for novel Lipid II-targeting antibiotic
compounds. To do this, we analyzed fungus-extracted
fractions by antibacterial activity assays in which Lipid II
was included to detect antagonism, TLC and LC-MS. We
identified eighteen Lipid II-targeting active fractions.
Further purification and characterization of one active
compound suggested a hydrophobic nature and a
corresponding m/z value of 805 or 1300. Further research
should elucidate the structure of the compound.

How to Cite
ZAALBERG, Irene. Detection of novel Lipid II-targeting antibiotics from fungi. Student Undergraduate Research E-journal!, [S.l.], v. 5, p. 1-4, dec. 2019. ISSN 2468-0443. Available at: <https://journals.open.tudelft.nl/sure/article/view/4193>. Date accessed: 06 july 2020. doi: https://doi.org/10.25609/sure.v5.4193.
Published
2019-12-03