Detection of novel Lipid II-targeting antibiotics from fungi
Bacterial resistance to antibiotics is one of the biggest
threats to global health today. Therefore, there is a pressing
need for new antibiotics. In this study, we examined four
fungal strains for novel Lipid II-targeting antibiotic
compounds. To do this, we analyzed fungus-extracted
fractions by antibacterial activity assays in which Lipid II
was included to detect antagonism, TLC and LC-MS. We
identified eighteen Lipid II-targeting active fractions.
Further purification and characterization of one active
compound suggested a hydrophobic nature and a
corresponding m/z value of 805 or 1300. Further research
should elucidate the structure of the compound.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted under the conditions of the Creative Commons Attribution-Share Alike (CC BY-SA) license and that copies bear this notice and the full citation on the first page.