The Effects of Exercise on the Tumor Immune Microenvironment

  • Ricky Siebeler Wageningen University and Research Centre
  • Vincent de Boer Wageningen University and Research Centre


This review explores the current understanding of the immunomodulatory effects of exercise, and the effectiveness of utilizing exercise as a therapy for cancer. Physical exercise has been shown to reduce the risk of developing cancer and appears to possess tumor-suppressive capabilities in existing solid tumors by modulating the tumor immune microenvironment. The current literature suggests exercise to enhance intra-tumoral tumor-suppressive immune cell activity through multiple pathways. The immunomodulating capabilities of exercise are likely dependent on anti-tumor immunity pathways. Exercise appears to be a viable tumor-suppressive strategy, depending on the state of anti-tumor immunity.

How to Cite
SIEBELER, Ricky; DE BOER, Vincent. The Effects of Exercise on the Tumor Immune Microenvironment. Student Undergraduate Research E-journal!, [S.l.], v. 5, p. 1-4, dec. 2019. ISSN 2468-0443. Available at: <>. Date accessed: 30 nov. 2020. doi: