Testing a sustainable source of Taxol for the treatment of RUNX cancers using Caenorhabditis elegans

Authors

  • David van de Klashorst HAN University of Applied sciences
  • Samantha Hughes HAN University of Applied sciences

DOI:

https://doi.org/10.25609/sure.v4.2812

Keywords:

C. elegans, RUNX, cancer, Taxol, fertility, Paclitaxel, Cephalomannine, 10-DAB

Abstract

RUNX proteins, master regulators of development, are frequently dysregulated in cancers, particularly leukaemia and breast cancer. A common drug for RUNX cancers, Paclitaxel, is derived from the bark of the Taxus plant. We tested compounds derived from leaves and needles of Taxus as a sustainable source of compounds to treat RUNX cancers. We accessed the effectiveness of Paclitaxel, Cephalomannine and 10-Deacetylbacatin III (10-DAB), in a Caenorhabditis elegans RUNX cancer model. Our results show Taxol derivatives have nuanced potency, affect development and fertility as well as reduce hyperproliferation. This research
paves the way for further C. elegans based research using Taxol compounds against RUNX.

Student Research Conference 2018

Additional Files

Published

2018-11-09

How to Cite

van de Klashorst, D., & Hughes, S. (2018). Testing a sustainable source of Taxol for the treatment of RUNX cancers using Caenorhabditis elegans. Student Undergraduate Research E-Journal!, 4. https://doi.org/10.25609/sure.v4.2812

Issue

Vol. 4 (2018): Student Research Conference 2018

Section

Biomedical Sciences & Health

License

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