The Link between Salivary Surfactant-Protein D and Dementia in Nursing Home Dementia Patients
Keywords:Dementia, surfactant protein D, innate immunity, saliva,
Recently, serumal surfactant protein D (SP-D) has been shown to correlate with the development of dementia.
As SP-D can be measured reliably in saliva, this might provide opportunities for a non-invasive biomarker. This
preliminary study aims to determine a possible difference between the levels of salivary SP-D in nondemented
elderly and late stage demented elderly. Results indicate a significant difference between demented subjects and controls, and between male and female demented subjects. This suggests SP-D could be used as a biomarker to improve detection of dementia. Further research should focus on early-stage dementia and the role of innate immunity in dementia.
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted under the conditions of the Creative Commons Attribution-Share Alike (CC BY-SA) license and that copies bear this notice and the full citation on the first page.