The Link between Salivary Surfactant-Protein D and Dementia in Nursing Home Dementia Patients
Recently, serumal surfactant protein D (SP-D) has been shown to correlate with the development of dementia.
As SP-D can be measured reliably in saliva, this might provide opportunities for a non-invasive biomarker. This
preliminary study aims to determine a possible difference between the levels of salivary SP-D in nondemented
elderly and late stage demented elderly. Results indicate a significant difference between demented subjects and controls, and between male and female demented subjects. This suggests SP-D could be used as a biomarker to improve detection of dementia. Further research should focus on early-stage dementia and the role of innate immunity in dementia.
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