Comparison between microscopically and macroscopically hippocampal activity in epilepsy patients

  • Lonieke Sillekens University of Amsterdam
  • Ilse van Straaten VU medical center

Abstract

Thirty percent of epilepsy patients do not respond to adequate antiepileptic drugs and for those patients, epilepsy surgery is an option. The invasive measurements of depth electroencephalography are used to localize the seizure onset zone, which is later resected to achieve seizure freedom, but are complicated because of their invasive nature. In this study, dEEG measurements of the hippocampus were compared to anatomically-matched virtual electrodes reconstructed out of MEG signals, to investigate whether restating-state non-invasive measurements reflect resting-state activity that is measured invasively with dEEG Our findings indicate MEG being a possible clinical replacement for depth EEG in the future.

References

1. Fisher RS, Van Emde Boas W, Blume W, et al.
Epileptic seizures and epilepsy: Definitions
proposed by the ILAE and the IBE. Epilepsia.
2005;46(4):470-472.
doi:10.1111/j.0013-9580.2005.66104.x.

2. Diessen van E, Diederen S, Braun K, et al.
Functional and structural brain networks in
epilepsy: what have we learned? Epilepsia
2013; 54(11):1855-65. doi: 10.1111/epi.12350

3. Refractory Epilepsy. Epilepsia. 2003;44:81-82.
doi:10.1046/j.1528-1157.44.s6.33.x.

4. Aydin Ü, Vorwerk J, Dümpelmann M, et al.
Combined EEG/MEG Can Outperform Single
Modality EEG or MEG Source Reconstruction
in Presurgical Epilepsy Diagnosis. 2014.
doi:10.1371/journal.pone.0118753.

5. Stam CJ, van Straaten ECW. The organization
of physiological brain networks. Clin
Neurophysiol. 2012;123(6):1067-1087.
doi:10.1016/j.clinph.2012.01.011.

6. Hillebrand A, Barnes GR, Bosboom JL,
Berendse HW, Stam CJ. Frequency-dependent
functional connectivity within resting-state
networks: An atlas-based MEG beamformer
solution. Neuroimage. 2012;59(4):3909-3921.
doi:10.1016/j.neuroimage.2011.11.005.

7. Santiuste M, Nowak R, Russi A, et al.
Simultaneous magnetoencephalography and
intracranial EEG registration: technical and
clinical aspects. J Clin Neurophysiol.
2008;25(6):331-339.
doi:10.1097/WNP.0b013e31818e7913.

8. Huiskamp G, Agirre-Arrizubieta Z, Leijten F.
Regional differences in the sensitivity of MEG
for interictal spikes in epilepsy. Brain Topogr.
2010;23(2):159-164.
doi:10.1007/s10548-010-0134-1.
How to Cite
SILLEKENS, Lonieke; VAN STRAATEN, Ilse. Comparison between microscopically and macroscopically hippocampal activity in epilepsy patients. Student Undergraduate Research E-journal!, [S.l.], v. 1, nov. 2015. ISSN 2468-0443. Available at: <https://journals.open.tudelft.nl/index.php/sure/article/view/1080>. Date accessed: 26 may 2019.
Published
2015-11-20