Physiologically-Based Pharmacokinetic Predictions of Lorazepam Paediatric Clearance

  • Tamara van Donge Leiden University
  • Elisa Calvier Leiden University


Drug clearance is an important pharmacokinetic parameter as it describes the rate of elimination of a drug from the body. The aim of this project was to develop a physiologically-based pharmacokinetic model, with the simulation program Simcyp, to predict the total plasma clearance for lorazepam for the entire paediatric age-range. The mean prediction error for observations in literature were 30% or below for all ages. This model can be used to assess the current dosing recommendations in children of all ages.


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Author Biographies

Tamara van Donge, Leiden University
Division of Pharmacology - LACDR
Elisa Calvier, Leiden University
Division of Pharmacology - LACDR
How to Cite
VAN DONGE, Tamara; CALVIER, Elisa. Physiologically-Based Pharmacokinetic Predictions of Lorazepam Paediatric Clearance. Student Undergraduate Research E-journal!, [S.l.], v. 1, nov. 2015. ISSN 2468-0443. Available at: <>. Date accessed: 20 mar. 2019.