Physiologically-Based Pharmacokinetic Predictions of Lorazepam Paediatric Clearance
AbstractDrug clearance is an important pharmacokinetic parameter as it describes the rate of elimination of a drug from the body. The aim of this project was to develop a physiologically-based pharmacokinetic model, with the simulation program Simcyp, to predict the total plasma clearance for lorazepam for the entire paediatric age-range. The mean prediction error for observations in literature were 30% or below for all ages. This model can be used to assess the current dosing recommendations in children of all ages.
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